The Marvelous
Microbiome

The microbiome refers to the genetic material of literally trillions of microbes – bacteria, fungi, protozoa and viruses – that live inside and on the human body.

Scientists have called it the second genome, and in fact, the number of genes in the microbes making up one person’s microbiome is 150 times greater than the number in the human genome. All humans are 99.9% similar in terms of their host genome, yet we can be 80-90% different in terms of microbiome.

Microbiome by the Numbers

Human Microbiome

~3,300,000 genes

Human Genome

~22,000 genes

37 trillion

estimated average number of cells in a human

10-100 trillion

one person’s number of symbiotic microbial cells

1,200

species of microbes found in human intestines

>100

species of microbes living in a human stomach

Gut Feeling

Each person’s microbiome is also constantly changing and evolving, and it has long been speculated and explored that this balance of microbes has a direct impact on differences between a healthy state and the presence of inflammation or disease, including certain cancers.

Over the last decade, there has been rapid acceleration in scientific understanding of the composition and functions of the gut microbiota. Today, around 200 companies are focused on understanding the human microbiome and its linkage to areas including infectious diseases and oncology, with the goal of identifying therapeutic targets.


New Frontier

Arranta Bio is proud to be building a business dedicated to meeting the supply needs of these innovators, having gained knowledge through the development and manufacture of over 125 live biopharmaceutical products (LBPs).

12 examples of conditions
in which problematic gut
bacteria may play a role:

  • 1 Diabetes
  • 2 Cancer
  • 3 Heart Disease
  • 4 Inflammatory Bowel Disease
  • 5 Irritable Bowel Syndrome (IBS)
  • 6 Obesity
  • 7 HIV
  • 8 Liver Diseases
  • 9 Asthma
  • 10 Rheumatoid Arthritis
  • 11 Celiac Disease
  • 12 Autism
  • Microbiome CDMO Services

    Building on the foundation of Captozyme, Arranta Bio offers development and cGMP manufacture of live biotherapeutic products (LBPs) for clinical and commercial supply.

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